Compared with the HIBI group, the relative CXCL1 expression in the NEC + HIBI group increased significantly at 3 (1.82 ± 0.29 vs. 1.16 ± 0.17), 24 (3.17 ± 0.07 vs. 1.97 ± 0.31), and 72 (4.26 ± 0.25 vs. 2.70 ± 0.17) h (P < 0.01), while CXCR2 expression was notably upregulated only at 24 h (2.21 ± 0.14 vs. 1.09 ± 0.13, P < 0.001). Here, CXCR2 is linked to necrotizing enterocolitis.