By contrast, ECM genes, VEGF signaling members Vegfa and Vegfc and Notch1 signaling genes Dll1, Jag1 and Numb were upregulated by sustained obesity in lung cap ECs but were not attenuated by a reversion diet (Extended Data Fig. 10l). The gene discussed is DLL1; the disease is obesity due to melanocortin 4 receptor deficiency.