Other hypertension-associated genes impacted by obesity included Podxl and Ebf1 upregulated in lung art ECs, Nbeal1 and Tbx3 upregulated in heart art ECs and Igfbp3 with reduced expression in heart, kidney and brain art ECs (Fig. 7e–i). This evidence concerns the gene IGFBP3 and obesity due to melanocortin 4 receptor deficiency.