As expected, Nrg4 replenishment reduced both theatherosclerotic lesion area in AKO mice but not significantly in CKO/AKO mice(Extended Data Fig. 7g–j),confirming the crucial role of ErbB4 in the anti-atherosclerotic effect of Nrg4.Based on these data, we can conclude that Nrg4 regulates NF-κB signalingand endothelial phenotype as well as atherosclerosis via ErbB4 receptor invivo. This evidence concerns the gene NRG4 and atherosclerosis.