ELN and Wilson disease: The results showed that Nrg4deficiency impaired endothelium-dependent relaxation (by 35% in KO-WD mice and28% in KO-NCD mice) (Fig. 1c), increasedendothelial cell apoptosis (Fig. 1a,b),decreased the intact endothelium (only the elastin layer remained from theintima with some debris from the endothelial layer) (Fig. 1e) compared to those of WD-WT and NCD-WT miceand these effects were more severe in WD-fed mice than NCD-fed mice.