In conclusion, our data demonstrate that BAT-derived Nrg4 inhibitedendothelial inflammation, decreased leukocyte homing and macrophage accumulation inplaques as well as improved plaque stability, consequently protecting againstendothelial injury and atherosclerosis in a manner involving theErbB4–Akt–NF-κB pathway (Fig. 8). The gene discussed is NRG4; the disease is atherosclerosis.