Last, thelevels of inflammatory cytokines, including IL-1β, IL-6 andTNF-α, as well as adhesion molecules, including VCAM-1, ICAM-1 andE-selectin in both plasma (Supplementary Table 2) and MAECs (Fig. 1f) of KO mice were significantly higher than those in WT mice,which were more severe in WD mice when compared to NCD mice. This evidence concerns the gene ICAM1 and Wilson disease.