Accordingly, BKO/AKO mice present a higher expressionof inflammatory cytokines and adhesion molecules in MAECs (Extended Data Fig.2f), a larger atherosclerotic areaboth in en face and cross-sectional of the aortas than those in WT mice (Fig.3e–h), as well as increasedplaque instability (Fig. 3i–n).Collectively, the deficiency of BAT-derived Nrg4 aggravates endothelium injuryand atherosclerosis. Here, NRG4 is linked to atherosclerosis.