In recent literature, it was reported that in a rat model of tongue cancer pain, P2X7R was predominantly expressed in microglia in the caudal subnucleus of the trigeminal spinal tract nucleus, and the administration of P2X7R-specific antagonist BBG inhibited pannexin 1 /IL-1β and thus effectively relieved tongue cancer pain [59]. The gene discussed is IL1B; the disease is tongue cancer.