Recent research has demonstrated that P2X7R/PRG-1/PP2A plays an important role in regulating synaptic plasticity in the hippocampus of rats with BCP in the development of cancer pain and depressive behavior and that both P2X7R inhibitors and PRG-1 agonists by injection into the hippocampal region can effectively alleviate cancer pain and depressive-like behavior in rats [56]. The gene discussed is PTPA; the disease is cancer.