In conclusion, our study identified a small set of genes (11 candidate genes including STX12, PHF14, ECT2, PRIM2, CENPL, CTHRC1, INHBA, RNFT2, CLSPN, ESM1, and COL10A1) that could be used to distinguish gastric cancer from normal tissues in TCGA cohort by using the combination feature selection methods of limma and JMI. The gene discussed is ESM1; the disease is gastric cancer.