Our observation that gene expression of Hyaluronan synthase 2 and 3 and Hyaluronidase 2, 3 and 5 in fibrosarcoma patients is linked to reduced patient survival is consistent with the observation that Hyaluronan synthase 1 but not 2 suppresses the motility of adult fibrosarcoma cells, by synthesising high molecular weight variants of hyaluronan, which increase cell adhesion of fibrosarcoma cells37. This evidence concerns the gene HYAL2 and fibrosarcoma.