Orthotopic murine breast (EO771), subcutaneous murine glioblastoma (Glioma261), and subcutaneous human pancreatic (HPAC) tumors also showed significantly reduced growth upon host global TEM8 disruption (Fig. 1a–c), providing further evidence that TEM8 in tumor-associated stroma has a broad impact on tumor growth independent of cancer type. Here, ANTXR1 is linked to neoplasm.