ANTXR1 and breast neoplasm: To determine if TEM8-mediated growth promotion could be observed in other inbred strains, C57BL6 TEM8 KO mice were backcrossed onto a BALB/C background where similar results were obtained using RENCA kidney, CT26 colon, and 4T1 breast tumor models (Fig. 1d and Supplementary Fig. 1a, b).