PRKDC and neoplasm: MC38 tumor growth was reduced similarly in TEM8 KO versus WT mice on a syngeneic immunocompetent C57BL/6, immunodeficient NU(NCr)-Foxn1nu (athymic nude), or a B6.CB17-Prkdc (SCID) background indicating that the pro-tumorigenic function of TEM8 is largely independent of the adaptive immune system (Supplementary Fig. 3).