ANTXR1 and neoplasm: Based on its specificity and high affinity for TEM8 (KD:1.6 to 3.7  nM for hTEM8 and mTEM8, respectively), ability to block col1, high production yields (>100 mg/L), potent anti-tumor activity and lack of toxicity, the m830 antibody has become our lead fully-human IgG for translation to clinical development.