NOX4 and systemic sclerosis: The analysis of gene expression values shows strong correlation between the fibrotic genes COL3A1, IL1A, and IL1B (r = 0.77 to 0.825), between micronuclei formation and activation of cGAS (r = 0.6095) and IFNB1 (r = 0.9562), between activation of the ROS genes NOX4 and CDKN1A, and between the SSc pro-fibrotic gene TGFB1 (r = 0.846 and 0.954, respectively) (Supplementary Figs. 10 and 11).