Given that ROS could produce centromere alterations and CIN as well as modulate TGFB1 activation and fibrosis in SSc8, we measured the levels of ROS-derived genes, finding significant overexpression of CDKN1A and NOX4 in SSc fibroblasts (Fig. 5, Supplementary Fig. 9). The gene discussed is NOX4; the disease is systemic sclerosis.