In fact, while HSPB8 exerts a pro-migratory ability in breast cancer [46], intrahepatic cholangiocarcinoma [60] and ovarian cancer [57], in which HSPB8 plays a pro-tumoral role, we found that HSPB8 reduces the migratory properties of both cell lines analyzed highlighting how this protein can reduce the metastatic potential of melanomas with different mutational status. This evidence concerns the gene HSPB8 and melanoma.