In order to gain information on the molecular mechanism by which HSPB8 exerts its action in melanoma, we transiently transfected mutated forms of HSPB8 (HSPB8K141E and HSPB8K141N) in BLM (Fig. 5a) and A375 cells (Fig. 5b). The gene discussed is HSPB8; the disease is melanoma.