HSPB8 and breast carcinoma: In fact, while HSPB8 exerts a pro-migratory ability in breast cancer [46], intrahepatic cholangiocarcinoma [60] and ovarian cancer [57], in which HSPB8 plays a pro-tumoral role, we found that HSPB8 reduces the migratory properties of both cell lines analyzed highlighting how this protein can reduce the metastatic potential of melanomas with different mutational status.