NRAS and melanoma: These mutations can occur in driver and mutually exclusive genes, such as BRAF and NRAS. Although other genes may be mutated in melanomas with concurrent BRAF or NRAS mutations, the melanoma classification falls in three-group based on the presence of: (i) mutant BRAF, (ii) mutant NRAS, (iii) or non-BRAF-mutant / non-NRAS-mutant [4].