RPTOR negatively regulates the mTOR complex 1 pathway, which plays roles in cell growth and immune responses and impacts dopamine neuron structure, as recently demonstrated in animal studies (Kosillo et al., 2022), and its DNA methylation has been associated with cardiovascular diseases and cancers (Zhu et al., 2022; Palou-Márquez et al., 2021). The gene discussed is RPTOR; the disease is cardiovascular disorder.