NRAS, the third member of the RAS family after relaying KRAS and HRAS in human neuroblastoma and fibrosarcoma cell lines, encodes a small GTPase that regulates cellularity by transducing membrane-localized receptor tyrosine kinase signals to the nucleus, regulating the cell cycle, proliferation, maturation, and differentiation [32]. This evidence concerns the gene NTRK1 and neuroblastoma.