To verify IPA’s prediction of the nuclear presence of Caspase-8, we separated the lysates of HeLa, SiHa, and two High-Grade Serous Ovarian Cancer (HGSOC) cell lines—OVCAR-3 [63] and OVCAR-8 [64], into their cytosol and nuclear fractions. Here, CASP8 is linked to ovarian serous adenocarcinoma.