CASP8 and cervical carcinoma: Additionally, our observation that in cervical cancer patients with low TMB, low Caspase-8 expression elicits a significantly better prognosis than in patients with high Caspase-8 expression (Fig. 1B) could be explained by the possibility that during the early stages of cervical cancer development, localized cervical cancer cells are not overtly dependent on the altered expressions of metastasis inducing genes.