Interestingly, cellular Hsp70 levels in tumor cells are generally higher than those in normal cells, even in the absence of stress (Hantschel et al. 2000; Ciocca and Calderwood 2005; Rohde et al. 2005; Akerfelt et al. 2010; Pockley and Henderson 2018) to protect cells from apoptosis and mediate therapy resistance. The gene discussed is HSPA1A; the disease is neoplasm.