Moreover, extracellular Hsp70 levels have been found to affect tumor associated immune responses (Linder and Pogge von Strandmann 2021; Pockley and Henderson 2018) and exosomal Hsp70 acts as a regulator of tumor-associated immune cells which determines immunosurveillance and evasion (Multhoff et al. 2001; Lee et al. 2006; Specht et al. 2015; Barreca et al. 2017; Taha et al. 2019). This evidence concerns the gene HSPA1A and neoplasm.