An autosomal dominant or recessive myopathy (OMIM# 601419) with weakness in the distal lower limbs and the quadriceps due to desmin mutations belongs now to the group of myofibrillary myopathies, similarly to the autosomal dominant hereditary myopathy with early respiratory failure (OMIM# 607569) caused by a mutation in titin (TTN). This evidence concerns the gene TTN and myopathy.