APOC1 and Alzheimer disease: Our prior analysis identified that the ε4-bearing compound genotypes examined in the current study of AD biomarkers exerted 89% (OR [odds ratio] = 1.89, p = 4.69 × 10−13) higher odds of AD when the ε4 alleles clustered with minor alleles of TOMM40 rs2075650 and APOC1 rs12721046 SNPs than major alleles of these two SNPs, i.e., when the 1XY+2XY compound genotype (carriers of the ε4 alleles who also carry minor alleles of rs2075650 and rs12721046) was contrasted by 100+200 genotype (carriers of the ε4 alleles who do not carry minor alleles of rs2075650 and rs12721046) [32].