TOMM40 and Alzheimer disease: We performed the analysis of the associations of the APOE ε2 and ε4 alleles and polygenic profiles represented by combinations of variants of the ε4 encoding rs429358, TOMM40 rs2075650, and APOC1 rs12721046 SNPs with CSF and plasma Aβ40, Aβ42, and tau AD biomarkers.