Associating gene expression with suppression of viral infection is a reasonable strategy to identify ISGs with obvious antiviral performance, exemplified by the influenza inhibitor, MX dynamin like GTPase 1 (MX1), and the human immunodeficiency virus 1 inhibitor, MX dynamin-like GTPase 2 (MX2) [21]. The gene discussed is MX1; the disease is viral infectious disease.