NF2 and malignant pleural mesothelioma: To confirm whether TM2 functions through blockade of TEAD-YAP binding, we tested TM2 in malignant pleural mesothelioma (MPM) cell line NCI-H226 cells, which is deficient with NF2 and highly dependent on TEAD-YAP activities (Kaneda et al., 2020; Tang et al., 2021).