For example, a recent study proposed that an R495W mutation in cMyBP-C (encoded by MYBPC3), a myosin-associated protein located along the myosin thick-filament backbone in muscle (Bennett et al., 1986), decreases its mechanical stability and causes hypertrophic cardiomyopathy (Suay-Corredera et al., 2021). Here, MYBPC3 is linked to hypertrophic cardiomyopathy.