Nevertheless, mounting evidence indicates that at least a subset of UM express estrogen receptors (ER) and luteinizing hormone‐releasing hormone (LHRH) receptors, and that ER expression may correlate to poor prognostic factors such as epithelioid or mixed tumor cell type, BAP1 mutations and monosomy of chromosome 3.41, 42, 43. This evidence concerns the gene ESR1 and neoplasm.