Because the encoded HoxC8 and HoxC6 proteins promote IAV replication, active loop formation at the HoxC8-HoxC6 loci, as a consequence of NP-dependent disruption of the Suv4-20h2-cohesin interaction, contributes to influenza-induced pathology [85] (Fig. 2F, right). This evidence concerns the gene HOXC8 and influenza.