In general, increased iron uptake (e.g., due to TFR overexpression), reduced iron storage (e.g., due to ferritin knockdown or induction of ferritin phagocytosis), and impaired cellular iron output (e.g., due to FPN knockdown) enhanced the sensitivity of cells to ferroptosis [22].Although in many types of cancer, statins were thought to induce ferroptosis to exert antitumor effects [23]. Here, TFRC is linked to cancer.