BLCs are abundant on bone surfaces.(5, 24, 25) Teriparatide, a parathyroid hormone used as an osteogenic agent in recent osteoporosis, and romosozumab, an antisclerostin antibody, have been reported to reactivate BLCs and contribute to bone formation.(7, 8, 9) In our study, we observed that activation of the Wnt signal by BIO administration induced a change in the flattened morphology of BLC‐like cells to a cuboidal morphology on the bone matrix and an increase in the bone matrix 2 weeks after administration. Here, PTH is linked to osteoporosis.