TK exerts its biological functions predominantly through the generation of kinin peptides and the subsequent activation of the kinin B2 receptor.5 In humans, diminished gene expression B2 receptor was found to be associated with pronounced left ventricular hypertrophy after a 10-week physical training course.10 According to Batista et al chronic swimming training led to cardiomyocyte enlargement and ventricular hypertrophy in both B2 receptor-ablated and wild-type mice. Here, TKT is linked to cardiac hypertrophy.