LEP and endothelial dysfunction: Adipokines are involved in the regulation of appetite and satiety (e.g., leptin), fat distribution, insulin secretion and sensitivity (e.g., leptin and adiponectin (ADIPOQ)), glucose metabolism (e.g., leptin, adiponectin), adipogenesis, and lipid metabolism and also in the accumulation of endothelial dysfunction and inflammation in the liver (e.g., TNF-α) [105,106].