Furthermore, NAMPT induces NF-κB and MAP kinase (MKK) 3/6-p38 signaling to increase CC chemokine ligand 20 (also called CCL20, an important cytokine for inflammation and fibrosis in the liver) expression in macrophages, which suggests that NAMPT can promote the activation of fibrotic markers in HSCs [143], which may be an important therapeutic target for the treatment of NAFLD. This evidence concerns the gene NFKB1 and metabolic dysfunction-associated steatotic liver disease.