Di Donato et al reported 10 patients with POLR3A mutations, mostly the c.1909 + 22G > A variant, to describe late‐onset spastic ataxia without hypomyelinating leukodystrophy, but they raise other exceptions such as seizures and non‐neurological features, and concluded that further expansions of variants and phenotypic presentations should be investigated.12 This evidence concerns the gene POLR3A and leukodystrophy.