In addition, Bifidobacterium pseudocatenulatum CECT 7765 restores the balance between regulatory T cells (Tregs) and B lymphocytes, and reduces the adaptive (IL-17A) and innate tumor necrosis factor-α (TNF-α) immunity and the pro-inflammatory cytokines of endotoxemia resulting in the reduction of obesity-associated systemic inflammation [20]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.