Earlier research demonstrated that immune checkpoint molecules (e.g., PD‐L1, LAG3) are involved in diverse biological processes and may serve as promising biomarkers for stratified prognosis or as excellent biomarkers for predicting the response to immune treatment in advanced urothelial carcinoma,30 colorectal cancer,31 and non‐small cell lung cancer.32 Here, CD274 is linked to colorectal cancer.