Increased soluble Fas (CD95/Apo-1), soluble Fas ligand, and activated caspase-3 have been found in the CSF, and caspase-3 signals have been detected by immunostaining in the periventricular zone of premature infants (25 weeks) with intraventricular hemorrhage, but not in infants without intraventricular hemorrhage (24 weeks) [29, 30]. This evidence concerns the gene CASP3 and Intraventricular hemorrhage.