CD80 and atherosclerosis: However, the confusing results showed that Ldlr−/− mice transferred with B7.1/2−/− bone marrow developed atherosclerosis more easily due to T cell priming relying on less costimulation in bone marrow transplantation.[101] In a recent study, an inhibitory effect on LPS-induced inflammation in atherosclerotic lesions was observed following administration of a specific B7-1 inhibitor.