In glioma studies, tumor cell-bound 4IgB7-H3 molecules suppressed NK cell-mediated tumor cell lysis by interacting with an unknown inhibitory receptor.[64] Recent research has shown that tumor-associated macrophage-related B7-H3 has a strong inhibitory effect on T-cells and influences the outcome of T-cell immune responses.[65] Furthermore, B7-H3 upregulate interleukin-10 (IL-10) secretion and downregulates IL-12 to promote tumor evasion and progression.[66]. This evidence concerns the gene CD276 and glioma.