BTLA and atherosclerosis: But for the combination members of BTLA, HVEM, and LIGHT, as the subjects, had been studied on inflammation atherosclerosis.[136,137] Stimulation of the BTLA pathway in Ldlr−/− mice reduced initial atherosclerotic lesion development and increased collagen, possibly by shifting CD4 + T cells towards Treg cells.[138] In the near future, research on these coinhibitory molecules will play an important role in the formation and development of atherosclerosis.