Adipose tissue produces adiponectin, tumor necrosis factor (TNF), alpha, leptin, resistin, and IL-6, thereby affecting insulin resistance and possibly pancreatic β-cell dysfunction.[3–5] New factors in the etiopathogenesis of diabetes mellitus include microbiological agents, due to direct infection of the pancreas, or saprophytic flora disorder.[8] Homeostatic microbiome (HM) is a set of all microorganisms (bacteria, fungi, and viruses) which by their mutual relationship and action maintain the normal homeostasis of the organism.[6]. This evidence concerns the gene TNF and Insulin resistance.