Moreover, a study investigating 180 American families identified 10 carriers, suggesting that BRCA2 mutations accounted for 6% of families with moderate- and high-risk pancreatic cancer.[50] The prevalence of deleterious mutations in the BRCA2 (excluding variants of unknown significance) was 3.7% among family members with prior evidence of pancreatic cancer. Here, BRCA2 is linked to familial pancreatic carcinoma.