This syndrome is not only associated with early onset breast and ovarian cancer but also increases the risk of pancreatic, gastric, laryngeal, fallopian tube, malignant skin, eye melanoma, and prostate cancer.[2,3] In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy. The gene discussed is BRCA2; the disease is prostate carcinoma.