BRCA2 and pancreatic neoplasm: However, 5 to 10% of patients with a family history of PDAC are estimated to be familial, and there are at least 12 known genetic syndromes or genes associated with an increased risk of pancreatic cancer, the most prominent of which contains the BRCA2 gene.[49] The frequency of BRCA gene mutations, particularly in BRCA2, is also increasing in familial pancreatic cancer.