Further analysis showed that the gefitinib-metformin combination synergistically inhibited BC growth through the epidermal growth factor receptor (EGFR), AKT, and ERK-linked AMPK pathways.[70] Therefore, the combination of these 2 drugs strongly inhibits cancer cell proliferation, clonal colony formation, and induces cancer cell apoptosis. The gene discussed is EGFR; the disease is breast cancer.