The inflammatory response is closely associated with tumors, and patients with tumors have high levels of inflammatory markers.[67,68] Metformin can reduce the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), macrophage migration inhibitor, C-reactive protein, and other inflammatory marker in the human body, thus exerting an anti-tumor role. The gene discussed is TNF; the disease is neoplasm.