SIRT5 and cancer: Pyruvate kinase M2 (PKM2), an important metabolic kinase in the Warburg effect of tumor cells, regulates the final step of glycolysis to ensure an adequate energy supply to the cells.[41] Increasingly, studies have proven that PKM2 is overexpressed in various cancers and has a negative effect on the proliferation of tumor cells, affecting various biological processes of tumor cells.[42] Studies have shown that SIRT5 interacts directly with PKM2.