SIRT5 and colonic neoplasm: SIRT5 desuccinylates CS at K393 and K395, Supersuccinylation of those sites significantly decrease their enzyme activity, thereby inhibiting the development of colon cancer.[53] Additionally, human RIDA (hRIDA) has been proven to be a carcinogenic antigen, and its expression is negatively correlated with tumor differentiation.[54,55] Studies indicate that hRIDA is expressed in most cell lines and is regulated by lysine succinylation, which is negatively correlated with the cell proliferation rate and regulated by SIRT5.[56]