For instance, AKT3 has been shown to regulate the expression of miR-29a, which acts as a tumor suppressor in papillary thyroid carcinoma.[30] AKT3 has also been shown to negatively regulate miR-384, which inhibits the proliferation of colorectal cancer cells.[25] In the current study, we utilized prediction software to understand how miR-497 participates in OA progression. The gene discussed is AKT3; the disease is thyroid gland papillary carcinoma.