PVT1 and cancer: For instance, a previous study reported that the levels of lncRNA DLEU1 elevated in colorectal cancer cases and that it promotes the malignant growth of cancer cells.[7] Another study showed that high expression of lncRNA UCA1, which acts as a carcinogenic factor, is associated with poor prognosis of OA patients.[8] The lncRNA SNHG5 has been shown to promote the proliferation and migration of chondrocytes through the miR-26a/SOX2 axis, suggesting its involvement in the progression of OA.[9] The lncRNA plasmacytoma variant translocation 1 (PVT1) is located at chromosome 8q24.21 in humans.