Nonetheless, it could be speculated that this finding might reflect a more pronounced dependence of clinical benefits of ticagrelor on an intact three-way synergism between P2Y12 blockade and endothelial mediators, PGI2 and NO [30, 32, 70, 71] in T2DM, owing to platelet hyperactivity in diabetic patients [7, 38, 39]. The gene discussed is P2RY12; the disease is type 2 diabetes mellitus.