Ten CpG loci were closely associated with BMI, with substantial overlap with obesity and insulin-related genes, including the melanocortin 2 receptor (MC2R), insulin-like growth factor binding protein like 1 (IGFBPL1), inositol hexakisphosphate kinase 1 (IP6K1) and insulin like growth factor 2 MRNA binding protein 1 (IGF2BP1) [69]. This evidence concerns the gene MC2R and obesity due to melanocortin 4 receptor deficiency.