Furthermore, 18 obesity and 21 candidate genes for T2D had different CpG loci that responded to exercise in adipose tissue DNAm, including transcription factor 7 like 2 (TCF7L2) and KCNQ1. The mRNA expression of these six genes changed simultaneously. The gene discussed is TCF7L2; the disease is obesity due to melanocortin 4 receptor deficiency.