SMAD3 and obesity due to melanocortin 4 receptor deficiency: The overlap analysis yielded many genes mapped by common differentially methylated CpG loci that were identified to reflect obesity status in leukocytes, including the fibroblast growth factor receptor like 1 (FGFRL1), non-SMC condensin II complex subunit H2 (NCAPH2), PNKD metallo-beta-lactamase domain containing (PNKD), and SMAD family member 3 (SMAD3) [59].