Furthermore, DNAm levels in several genes such as protein tyrosine phosphatase receptor type S (PTPRS), period3 (PER3), adenylate cyclase activating polypeptide receptor 1 (ADCYAP1R1), N-methyl-D-aspartate receptor subtype 2D (GRIN2D), glutamate receptor, ionotropic, and vasoactive intestinal peptide receptor 2 (VIPR2) were associated with obesity traits. This evidence concerns the gene VIPR2 and obesity due to melanocortin 4 receptor deficiency.