The differentially methylated CpG loci included 23 genes known to be associated with obesity, adiposity, T2D and MetS, as well as potentially novel metabolic genes (ATP10A, BCAS3, BCL2, CDKAL1, CMIP, CTSZ, ETV5, FBP2, GGT1, HHEX, HK1, KCNQ1, LGALS2, MAP2K5, NR1H3, PNOC, PRDM2, RPTOR, SLC39A12, ST3GAL4, THADA, TNNI3K and UBASH3A). The gene discussed is KCNQ1; the disease is obesity due to melanocortin 4 receptor deficiency.