The high-level of the cg02814054 locus increased the risk of obesity by reducing the expression of microtubule associated serine/threonine kinase 3 (MAST3), while low-level methylation of cg06028605 increased the risk of obesity by decreasing the expression of solute carrier family 5 member 11 (SLC5A11). This evidence concerns the gene SLC15A1 and obesity due to melanocortin 4 receptor deficiency.