In conclusion, 5 Hypo­HGs (HOXD9, RAI2, ADPRHL1, C12orf42, and PCDHB16) and 13 Hyper-LGs (EPCAM, GNG4, SLFN13, USH1C, SPINT1, SLC39A4, LYZ, SPARCL1, DGKK, WNK2, DNAH9, STRA8, and ST8SIA3) were identified in NAFLD patients HCC with cirrhosis. This evidence concerns the gene ST8SIA3 and metabolic dysfunction-associated steatotic liver disease.