At present, EPCAM was a hub gene in PPI network and one of the top 10 DEGs, as well as Hyper-LG, in NAFLD HCC patients with cirrhosis, which indicated that EPCAM may exert a momentous role in inflammatory response and tumorigenesis in NAFLD of HCC with cirrhosis. Here, EPCAM is linked to metabolic dysfunction-associated steatotic liver disease.