NOD-like receptor (NLRP3) is important in the formation and activation of inflammatory bodies [68] and is associated with transforming growth factor beta-1 (TGFβ1) [69], monocyte chemoattractant protein-1 (MCP-1) [70], and tumor necrosis factor ligand superfamily member 2 (TNFSF2) [71], which together play a role in the development of vascular complications in DM. The gene discussed is CCL2; the disease is diabetes mellitus.