Guadecitabine induced frequent upregulation of genes of the following functional classes: cancer testis, adhesion molecules, positive/negative co-stimulation, myeloid-related, cytokines and receptors, T/NK- related, immune cell lineage/differentiation, regulation of inflammation, TNF/TNFR pathway, Type I-II-III IFN pathways and intracellular signaling (Fig. 2 and Suppl. This evidence concerns the gene IFNA1 and testicular cancer.