JQ1 was characterized by induction of inhibitory relationship linking regulators of inflammation (IFNG, IL17A, TGFB2), melanoma biological behavior (EGFR, WNT3A, TEADs, MRTFB), cell-cell interaction (CD44, CCN2), YAP pathway (LLGL2, NSUN6) and main transcriptional regulators (FOS, JUN, FOXM1). This evidence concerns the gene CD44 and melanoma.