This work demonstrated that compared with MACCE negative group in T2DM patients aged ≥ 65 years, the patients in positive group showed the higher levels of NGAL and sdlDL-C, which were associated with some other auxiliary diagnostic and therapeutic indicators such as BMI, TG, hsCRP, neutrophils, LDL-c, TG, ApoB, and ApoA-I. The gene discussed is APOA1; the disease is type 2 diabetes mellitus.