TP53 and neoplasm: We do agree that in certain circumstances, such as with a positive H3K27M stain or a positive triple-mutated IDH1-mutant/ATRX-lost/p53-mutant tumor, the immunoprofile can very quickly yield a definitive diagnosis; however, it is not clear that there is a clinically significant benefit to having this diagnosis in 2–3 days (IHC) versus 7–10 days (expedited NGS) versus 10–21 days (routine TAT for NGS at our institution) to merit routine use.