In addition, all EBV-positive tumours display amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also named PD-L2) and carry a lower number of mutations in genes such as TP53, CDH1, RHOA, than the other GC subgroups where these genes are found to be highly mutated [26, 33]. This evidence concerns the gene CD274 and neoplasm.