Matsusaka and colleagues, using Illumina’s Infinium Bead Array, identified three epigenotypes groups based on the EBV status and methylation degree: (1) genes specifically methylated in the EBVaGC (such as Timp2), (2) genes methylated both in EBV positive and EBV negative/high tumours (such as Eya1) and, (3) genes methylated in all gastric cancers [29, 30]. This evidence concerns the gene TIMP2 and neoplasm.