APP and Alzheimer disease: Strikingly, the family of Vacuolar protein sorting 10p-Domain (VPS10p-D) receptors plays a dual role in the pathobiology of AD: it controls APP and Aβ trafficking and clearance, and it regulates the balance between the trophic and apoptotic signaling by neurotrophins such as BDNF and its precursor proBDNF.