Interestingly, C-terminal fragments of Sortilin are deposited in neuritic Aβ plaques in human cerebrum [218] but not in brains from transgenic AD mouse models nor aged macaques exhibiting amyloid plaque deposition [220] suggesting the interspecies differences in the formation/composition of senile plaques in regards to VPS10p-D receptors. The gene discussed is SORT1; the disease is Alzheimer disease.