Indeed, a recent study discovered that a PrPC antagonist blocks the protein aggregation, and rescues the Aβ-related synapse loss and memory deficits in AD transgenic mice [267], similarly to mGluR5 antagonist [262]. Strikingly, Uchiyama et al. showed that Sortilin is neuroprotective against the prion spreading as it internalizes PrPC and PrPSc, and transports them into lysosomes for their degradation. The gene discussed is GRM5; the disease is Alzheimer disease.