PRNP and Alzheimer disease: Indeed, a recent study discovered that a PrPC antagonist blocks the protein aggregation, and rescues the Aβ-related synapse loss and memory deficits in AD transgenic mice [267], similarly to mGluR5 antagonist [262]. Strikingly, Uchiyama et al. showed that Sortilin is neuroprotective against the prion spreading as it internalizes PrPC and PrPSc, and transports them into lysosomes for their degradation.