AR and renal cell carcinoma: To examine the role of AR-regulated lncRNAs in hypoxia-induced CSC phenotypes in RCC, we altered the expression of these 3 lncRNAs and found that knocking down lncTCFL5-2 with two different sh-sequence plasmids could both significantly suppress RCC sphere formation under the influence of hypoxia (Fig. 2E, Additional file 1: Fig. S2E).