Independent risk factors affecting RFS included methemoglobin level ≥ 20 ng/ml (HR, 2.124; 95% CI 1.506–2.995; p < 0.001), alkaline phosphatase level > 130 IU/L (HR, 1.820; 95% CI 1.302–2.545; p < 0.001), tumor hypomedifferentiation (HR 1.462; 95% CI 1.067–2.002; p = 0.018), and tumor multiplicity (HR, 1.815; 95% CI 1.170–2.815; p = 0.008). The gene discussed is HBG2; the disease is neoplasm.