Our study showed that multiple factors were associated with early recurrence in multivariate COX regression analysis, including prolonged prothrombin time (≥ 13s), methemoglobin level ≥ 20ng/ml, platelet count ≥ 100 × 109/L, tumor size > 5 cm, multiple tumors, and not receiving antiviral therapy, while late recurrence was associated with AST levels > 40 IU/ml, ALP levels > 130 IU/L, and the presence of satellite nodules. The gene discussed is HBG2; the disease is neoplasm.