CX3CL1 and colon adenocarcinoma: Next, we performed a disease-specific survival (DSS) analysis, which showed that higher CX3CL1 expression was associated with worse prognosis in COAD (HR = 1.343, P = 0.010) and lower CX3CL1 expression was associated with worse prognosis in CESC (HR = 0.771, P = 0.003), KICH (HR = 0.241, P = 0.002), KIRC (HR = 0.540, P <  0.001), KIRP (HR = 0.502, P <  0.001), LGG (HR = 0.630, P <  0.001), LUAD (HR = 0.847, P = 0.012) and PRAD (HR = 0.364, P = 0.045) (Fig. 1D).