Additionally, we demonstrated that the knockdown of ENDRB or inhibition of ENDRB by Bosentan alleviated the pathological injury of the liver tissues and reduced the serum levels of ALP, AST, ALT, AMA-M2, IFN-γ, and TNF-α in PBC mouse models, suggesting the ameliorative effect of ENDRB loss on PBC. This evidence concerns the gene GPT and primary biliary cholangitis.