IGF2BP2 and hepatocellular carcinoma: To determine which reader proteins mediate the mRNA stability of Gys2, we independently depleted the six candidate readers in Hepa 1-6 (mouse hepatocellular carcinoma) cells and found that depletion of only IGF2BP2 reduced Gys2 mRNA expression (Fig. 4a, Supplementary Fig. 4a).