CALCA and malaria: Probably due to the massive KC death during malaria, the percentage of hemozoin-positive cells declined over time (after 30–100 days); however, when we normalized hemozoin positivity to the number of star-shaped cells (presumably mature and phagocytosis-capable cells), it is also reasonable to suggest that the vast majority of F4/80+ cells were harboring hemozoin crystals at this timepoint (Fig. 5B).