S100A8 and psoriasis: In parallel, analysis of DEGs from the shared signature that contribute to Role of IL-17A in Psoriasis Pathway revealed greater enrichment in psoriatic lesion skin than in intestinal UC lesional tissues versus the corresponding nonlesionnal samples, as evidenced by the overexpressed chemokines (CCL20, CXCL1, CXCL3, CXCL6) and S100 genes (S100A8, S100A9) (Table 2).